ALPI

Identifiers

ALPI, IAP, alkaline phosphatase, intestinal

External IDs

MGI: 87984 HomoloGene: 134333 GeneCards: ALPI

Gene ontology
Molecular function	• alkaline phosphatase activity • protease binding • phosphatase activity • zinc ion binding • protein binding • catalytic activity • hydrolase activity • magnesium ion binding • metal ion binding
Cellular component	• integral component of membrane • anchored component of membrane • plasma membrane • membrane
Biological process	• metabolic process • dephosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


248


11648

Ensembl


ENSG00000163295


ENSMUSG00000036500

UniProt


P09923


P24822

RefSeq (mRNA)


NM_001631


NM_007432

RefSeq (protein)


NP_001622.2


n/a

Location (UCSC)

Chr 2: 232.46 – 232.46 Mb

Chr 1: 87.12 – 87.13 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
↑ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.

Hirasaka K, Tokuoka K, Nakao R, et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells.". J Physiol Sci. 58 (2): 105–11. doi:10.2170/physiolsci.RP013007. PMID 18307834.
Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433–41. doi:10.1152/ajpgi.00466.2002. PMID 12660142.
Wada A, Wang AP, Isomoto H, et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.". Int. J. Med. Microbiol. 294 (7): 427–35. doi:10.1016/j.ijmm.2004.09.012. PMID 15715171.
Nakano T, Inoue I, Alpers DH, et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207–14. doi:10.1152/ajpgi.90590.2008. PMID 19407215.
Malo MS, Zhang W, Alkhoury F, et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element.". Mol. Endocrinol. 18 (8): 1941–62. doi:10.1210/me.2003-0351. PMID 15143152.
Rump A, Kasper G, Hayes C, et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1.". Genomics. 73 (1): 50–5. doi:10.1006/geno.2000.6504. PMID 11352565.
Nauli AM, Zheng S, Yang Q, et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation.". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583–7. doi:10.1152/ajpgi.00482.2002. PMID 12466148.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity.". Semin. Oncol. 29 (6 Suppl 19): 14–21. doi:10.1053/sonc.2002.37356. PMID 12577238.
Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease.". Pathol. Res. Pract. 203 (6): 485–7. doi:10.1016/j.prp.2007.02.003. PMID 17498884.
Hinnebusch BF, Siddique A, Henderson JW, et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. doi:10.1152/ajpgi.00203.2003. PMID 12919939.
Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases.". J. Biol. Chem. 277 (51): 49808–14. doi:10.1074/jbc.M207394200. PMID 12372831.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Goldberg RF, Austen WG, Zhang X, et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551–6. doi:10.1073/pnas.0712140105. PMC 2265168. PMID 18292227.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220–6. doi:10.1152/ajpgi.00449.2004. PMID 15831710.
Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.". EMBO J. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

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ALPI

References

Further reading