Inositol monophosphatase 3

IMPAD1

Identifiers

IMPAD1, GPAPP, IMP 3, IMP-3, IMPA3, inositol monophosphatase domain containing 1

External IDs

MGI: 1915720 HomoloGene: 9852 GeneCards: IMPAD1

Gene ontology
Molecular function	• inositol monophosphate 1-phosphatase activity • inositol monophosphate 4-phosphatase activity • hydrolase activity • inositol monophosphate phosphatase activity • 3'(2'),5'-bisphosphate nucleotidase activity • magnesium ion binding • metal ion binding • inositol monophosphate 3-phosphatase activity • 3'-nucleotidase activity
Cellular component	• integral component of membrane • membrane • Golgi apparatus
Biological process	• skeletal system development • chondrocyte development • embryonic digit morphogenesis • phosphatidylinositol phosphorylation • chondroitin sulfate metabolic process • endochondral ossification • post-embryonic development • inositol biosynthetic process • dephosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54928


242291

Ensembl


ENSG00000104331


ENSMUSG00000066324

UniProt


Q9NX62


Q80V26

RefSeq (mRNA)


NM_017813


NM_177730

RefSeq (protein)


NP_060283.3


NP_808398.1

Location (UCSC)

Chr 8: 56.96 – 56.99 Mb

Chr 4: 4.76 – 4.79 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.^[3]

This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).^[3]

Clinical significance

Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1.^[3]

References

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4: Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease and
ribonuclease)

3.1.11-16: Exonuclease

Exodeoxyribonuclease	RecBCD

Exoribonuclease	Oligonucleotidase

3.1.21-31: Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme UvrABC endonuclease

Endoribonuclease	RNase III RNase H 1 2A 2B 2C RNase P RNase A 1 2 3 4/5 RNase T1 RNA-induced silencing complex

either deoxy- or ribo-	Aspergillus nuclease S1 Micrococcal nuclease

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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