WNT11

Identifiers

WNT11, HWnt family member 11

External IDs

MGI: 101948 HomoloGene: 20970 GeneCards: WNT11

Gene ontology
Molecular function	• GTPase activator activity • frizzled binding • protein kinase activator activity • protein binding • transcription regulatory region DNA binding • receptor binding
Cellular component	• cytoplasm • proteinaceous extracellular matrix • extracellular fluid • extracellular region
Biological process	• ureteric bud morphogenesis • cellular response to retinoic acid • bone mineralization • palate development • cell differentiation • non-canonical Wnt signaling pathway • cell fate commitment • negative regulation of cartilage development • paraxial mesoderm formation • mesonephric duct development • convergent extension involved in axis elongation • positive regulation of protein kinase C signaling • kidney development • positive regulation of cell migration • ventricular septum morphogenesis • outflow tract morphogenesis • negative regulation of apoptotic process • negative regulation of cell death • adrenal gland development • planar cell polarity pathway involved in axis elongation • positive regulation of transforming growth factor beta2 production • somite development • embryonic skeletal system development • positive regulation of transcription, DNA-templated • multicellular organism development • protein phosphorylation • positive regulation of GTPase activity • maintenance of epithelial cell apical/basal polarity • positive regulation of gene expression • Wnt signaling pathway, calcium modulating pathway • negative regulation of cell migration • response to nutrient levels • protein localization to cell surface • notochord morphogenesis • negative regulation of cell growth • osteoblast differentiation • neuron differentiation • artery morphogenesis • bicellular tight junction assembly • epithelial to mesenchymal transition • positive regulation of apoptotic process • canonical Wnt signaling pathway • lung-associated mesenchyme development • negative regulation of transcription, DNA-templated • cloacal septation • negative regulation of mesenchymal cell proliferation • neuroendocrine cell differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of fibroblast growth factor production • positive regulation of stress fiber assembly • planar cell polarity pathway involved in gastrula mediolateral intercalation • Wnt signaling pathway, planar cell polarity pathway • Wnt signaling pathway • activation of protein kinase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7481


22411

Ensembl


ENSG00000085741


ENSMUSG00000015957

UniProt


O96014


P48615

RefSeq (mRNA)


NM_004626


NM_001285792 NM_001285794 NM_001285795 NM_009519

RefSeq (protein)


NP_004617.2


NP_001272721.1 NP_033545.1

Location (UCSC)

Chr 11: 76.19 – 76.21 Mb

Chr 7: 98.84 – 98.86 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Protein Wnt-11 is a protein that in humans is encoded by the WNT11 gene.^[3]^[4]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney, and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S (Dec 1998). "Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung". Gene. 219 (1–2): 101–10. doi:10.1016/S0378-1119(98)00393-X. PMID 9757009.
1 2 "Entrez Gene: WNT11 wingless-type MMTV integration site family, member 11".

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Kirikoshi H, Sekihara H, Katoh M (2002). "Molecular cloning and characterization of human WNT11". Int. J. Mol. Med. 8 (6): 651–6. doi:10.3892/ijmm.8.6.651. PMID 11712081.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ouko L; Ziegler TR; Gu LH; et al. (2004). "Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells". J. Biol. Chem. 279 (25): 26707–15. doi:10.1074/jbc.M402877200. PMC 1351009. PMID 15084607.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim SW; Park JI; Spring CM; et al. (2005). "Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin". Nat. Cell Biol. 6 (12): 1212–20. doi:10.1038/ncb1191. PMID 15543138.
Koyanagi M; Haendeler J; Badorff C; et al. (2005). "Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells". J. Biol. Chem. 280 (17): 16838–42. doi:10.1074/jbc.M500323200. PMID 15701629.
Garriock RJ, D'Agostino SL, Pilcher KC, Krieg PA (2005). "Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus". Dev. Biol. 279 (1): 179–92. doi:10.1016/j.ydbio.2004.12.013. PMID 15708567.
Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Panáková D, Werdich AA, Macrae CA (2010). "Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.". Nature. 466 (8): 874–878. doi:10.1038/nature09249. PMC 2921013. PMID 20657579.

Signaling pathway: Wnt signaling pathway

Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16

Receptor	Frizzled LRP5 LRP6

Second messenger	Dishevelled GSK-3 APC Beta-catenin

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WNT11

References

Further reading