Satavaptan

Satavaptan
Clinical data

ATC code	none
Identifiers
IUPAC name N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide
CAS Number	185913-78-4^Y
PubChem (CID)	9810773
ChemSpider	32699105^N
UNII	AJS8S3P31H^Y
ECHA InfoCard	100.211.853
Chemical and physical data
Formula	C₃₃H₄₅N₃O₈S
Molar mass	643.789 g/mol
3D model (Jmol)	Interactive image
SMILES CCOc1cc2c(cc1)N(C(=O)[C@@]23CC[C@@H](CC3)OCCN4CCOCC4)S(=O)(=O)c5c(cc(cc5)C(=O)NC(C)(C)C)OC CCOc1cc2c(cc1)N(C(=O)[C@@]23CC[C@@H](CC3)OCCN4CCOCC4)S(=O)(=O)c5c(cc(cc5)C(=O)NC(C)(C)C)OC
InChI InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+^N Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N^N
^NY (what is this?) (verify)

Satavaptan (INN; codenamed SR121463, planned tradename Aquilda) is a vasopressin-2 receptor antagonist^[1] undergoing research for the treatment of hyponatremia. It is also being studied for the treatment of ascites.^[2]

It was developed by Sanofi-Aventis. As of 2008, it is under regulatory review in the European Union.

References

↑ Soupart A, Gross P, Legros JJ, et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol. 1 (6): 1154–1160. doi:10.2215/CJN.00160106. PMID 17699341.
↑ Ginès P; Wong F; Watson H; Milutinovic S; Ruiz Del Arbol L; Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology. 48 (1): 204–213. doi:10.1002/hep.22293. PMID 18508290.

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozolin Muzolimine Ozolinone Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Other

V_1A	Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Conivaptan FR-218944 JNJ-17079166 JNJ-17308616 LY-307174 PF-184563 Relcovaptan RG7314 SRX246 SRX251 TC OT 39 WAY-267464 YM-218 YM-471 YM-35471

V_1B	Agonists: Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: ABT-436 Nelivaptan ORG-52186

V₂	Agonists: Desmopressin Felypressin Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Conivaptan JNJ-17079166 Lixivaptan Mozavaptan RWJ-351647 Satavaptan Tolvaptan YM-471 YM-35471

Unsorted	Antagonists: Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)

Others

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