Metallibure
| Clinical data | |
|---|---|
| Trade names | Aimax, Suisynchron, Turisynchron |
| Identifiers | |
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| Synonyms | ICI-33828; AY-61122; NSC-69536 |
| CAS Number | 926-93-2 |
| PubChem (CID) | 3003791 |
| ChemSpider | 2274191 |
| Chemical and physical data | |
| Formula | C7H14N4S2 |
| Molar mass | 218.337 g/mol |
| 3D model (Jmol) | Interactive image |
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Metallibure (INN) (brand names Aimax, Suisynchron, Turisynchron; former developmental code names ICI-33,828, AY-61122, NSC-69536), or methallibure (USAN, BAN) is a non-steroidal antigonadotropin that was introduced in 1973 and is used in veterinary medicine to synchronize estrus.[1][2] It was withdrawn in the United States and Europe due to teratogenicity and has been replaced with altrenogest.[2][3] The precise mechanism of action of metallibure is unknown.[2] However, it appears to act directly on the pituitary gland and/or hypothalamus to suppress gonadotropin secretion.[2]
Metallibure is similarly effective as an antigonadotropin in women.[4] It is associated with several unpleasant side effects including anorexia, nausea, occasional vomiting, lethargy, and drowsiness.[4] Animal toxicity studies revealed that the drug induced the development of cataracts, and this resulted in the termination of its clinical development.[4]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 781–. ISBN 978-1-4757-2085-3.
- 1 2 3 4 I. Gordon (22 October 2013). Controlled Breeding in Farm Animals. Elsevier. pp. 313–. ISBN 978-1-4832-8569-6.
- ↑ Brüssow KP, Schneider F, Kanitz W, Rátky J, Kauffold J, Wähner M (2009). "Studies on fixed-time ovulation induction in the pig". Soc Reprod Fertil Suppl. 66: 187–95. PMID 19848281.
- 1 2 3 JUCKER (21 December 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser. pp. 102–. ISBN 978-3-0348-7065-8.