Mucin 5AC

MUC5AC
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs MGI: 104697 HomoloGene: 137237 GeneCards: MUC5AC
Orthologs
Species Human Mouse
Entrez

4586

17833

Ensembl

ENSG00000215182

ENSMUSG00000037974

UniProt

P98088

n/a

RefSeq (mRNA)

NM_017511
NM_001304359

NM_010844

RefSeq (protein)

NP_001291288.1

n/a

Location (UCSC) Chr 11: 1.16 – 1.2 Mb Chr 7: 141.79 – 141.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[3][4][5]

Clinical relevance

This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD).[6]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. PMC 1136451Freely accessible. PMID 7826332.
  4. ↑ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
  5. ↑ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
  6. ↑ Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics. 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416Freely accessible. PMID 22676183.


This article is issued from Wikipedia - version of the 6/3/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.