HslU—HslV peptidase
| HslU—HslV peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Heat shock peptidase dodekamer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.25.2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
HslU—HslV peptidase (EC 3.4.25.2, HslUV, HslV-HslU, HslV peptidase, ATP-dependent HslV-HslU proteinase, caseinolytic protease X, caseinolytic proteinase X, ClpXP ATP-dependent protease, ClpXP protease, ClpXP serine proteinase, Escherichia coli ClpXP serine proteinase, HslUV protease, HslUV proteinase, HslVU protease, HslVU proteinase, protease HslVU, proteinase HslUV) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- ATP-dependent cleavage of peptide bonds with broad specificity.
This enzyme belongs to the peptidase family T1.
References
- ↑ Wang, J.; Rho, S.H.; Park, H.H.; Eom, S.H. (2005). "Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects". Acta Crystallogr. D. 61: 932–941. doi:10.1107/s0907444905009546. PMID 15983416.
- ↑ Nishii, W.; Takahashi, K. (2003). "Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli". FEBS Lett. 553: 351–354. doi:10.1016/s0014-5793(03)01044-5. PMID 14572649.
- ↑ Ramachandran, R.; Hartmann, C.; Song, H.K.; Huber, R.; Bochtler, M. (2002). "Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)". Proc. Natl. Acad. Sci. USA. 99: 7396–7401. doi:10.1073/pnas.102188799. PMID 12032294.
- ↑ Yoo, S.J.; Seol, J.H.; Shin, D.H.; Rohrwild, M.; Kang, M.S.; Tanaka, K.; Goldberg, A.L.; Chung, C.H. (1996). "Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli". J. Biol. Chem. 271: 14035–14040. doi:10.1074/jbc.271.24.14035. PMID 8662828.
- ↑ Yoo, S.J.; Seol, J.H.; Seong, I.S.; Kang, M.S.; Chung, C.H. (1997). "ATP binding, but not its hydrolysis, is required for assembly and proteolytic activity of the HslVU protease in Escherichia coli". Biochem. Biophys. Res. Commun. 238: 581–585. doi:10.1006/bbrc.1997.7341. PMID 9299555.
- ↑ Kanemori, M.; Nishihara, K.; Yanagi, H.; Yura, T. (1997). "Synergistic roles of HslVU and other ATP-dependent proteases in controlling in vivo turnover of σ32 and abnormal proteins in Escherichia coli". J. Bacteriol. 179: 7219–7225. PMID 9393683.
- ↑ Burton, R.E.; Baker, T.A.; Sauer, R.T. (2005). "Nucleotide-dependent substrate recognition by the AAA+ HslUV protease". Nat. Struct. Mol. Biol. 12: 245–251. doi:10.1038/nsmb898. PMID 15696175.
External links
- HslU---HslV peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 7/11/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.