PSMF1

PSMF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VT8, 4OUH
Identifiers
Aliases	PSMF1, PI31, proteasome inhibitor subunit 1
External IDs	MGI: 1346072 HomoloGene: 38231 GeneCards: PSMF1
Gene ontology Molecular function • proteasome binding • protein binding • endopeptidase inhibitor activity Cellular component • cytoplasm • cytosol • membrane • nucleoplasm • endoplasmic reticulum • proteasome complex • proteasome core complex Biological process • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • MAPK cascade • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of proteasomal protein catabolic process • anaphase-promoting complex-dependent catabolic process • T cell receptor signaling pathway • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of canonical Wnt signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9491	228769
Ensembl	ENSG00000125818	ENSMUSG00000032869
UniProt	Q92530 Q5QPM9	Q8BHL8
RefSeq (mRNA)	NM_006814 NM_178578 NM_178579 NM_001323407 NM_001323408 NM_001323409 NM_001323410	NM_144889 NM_212446 NM_001305244
RefSeq (protein)	NP_006805.2 NP_848693.2 NP_001310336.1	NP_997611.1
Location (UCSC)	Chr 20: 1.11 – 1.19 Mb	Chr 2: 151.72 – 151.74 Mb
PubMed search	[1]	[2]
Wikidata

Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene.^[3][4]

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.^[4]

References

Further reading