Clobutinol
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | oral |
| ATC code | R05DB03 (WHO) |
| Legal status | |
| Legal status |
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| Identifiers | |
| |
| CAS Number |
14860-49-2  |
| PubChem (CID) | 26937 |
| DrugBank |
DB09004  |
| ChemSpider |
25085 |
| UNII |
1NY2IX043A |
| KEGG |
D07716 |
| ChEMBL |
CHEMBL1474889 |
| ECHA InfoCard | 100.035.373 |
| Chemical and physical data | |
| Formula | C14H22ClNO |
| Molar mass | 255.783 g/mol |
| 3D model (Jmol) | Interactive image |
| Chirality | Racemic mixture |
| |
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| (what is this?) (verify) | |
Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.
Side effects and withdrawal
Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval.[1] Clobutinol was in 2007 determined to cause cardiac arrhythmia in some patients.[2]
Boehringer Ingelheim products containing clobutinol were voluntarily withdrawn from sale in Germany, and the rest of the world, on August 31, 2007.[3]
The approval for Germany and the EU was revoked in 2008.[4]
See also
References
- ↑ Bellocq, C.; Wilders, R.; Schott, J. J.; Louérat-Oriou, B.; Boisseau, P.; Le Marec, H.; Escande, D.; Baró, I. (2004). "A Common Antitussive Drug, Clobutinol, Precipitates the Long QT Syndrome 2". Molecular Pharmacology. 66 (5): 1093–1102. doi:10.1124/mol.104.001065. PMID 15280442.
- ↑ "Clobutinol-haltige Arzneimittel: BfArM ordnet Widerruf der Zulassung an.". BfArM (German Federal Institute for Drugs and Medical Devices). 2007-08-31.
Clobutinol: BfArM orders cancellation of approval
- ↑ "Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications.". Boehringer Ingelheim. 2007-08-31.
- ↑ "Cancellation of approval" (pdf). BfArM (German Federal Institute for Drugs and Medical Devices). 2008-06-06.
Die Zulassungen für die o.g. Arzneimittel werden mit sofortiger Wirkung widerrufen.
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