Calpain-3
| Calpain-3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.22.54 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Calpain-3 (EC 3.4.22.54, p94, calpain p94, CAPN3, muscle calpain, calpain 3, calcium-activated neutral proteinase 3, muscle-specific calcium-activated neutral protease 3, CANP 3, calpain L3) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Broad endopeptidase activity
This Ca2+ dependent enzyme is found in skeletal muscles.
See also
References
- ↑ Sorimachi, H.; Imajoh-Ohmi, S.; Emori, Y.; Kawasaki, H.; Ohno, S.; Minami, Y.; Suzuki, K. (1989). "Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and μ-types. Specific expression of the mRNA in skeletal muscle". J. Biol. Chem. 264 (33): 20106–20111. PMID 2555341.
- ↑ Sorimachi, H.; Kinbara, K.; Kimura, S.; Takahashi, M.; Ishiura, S.; Sasagawa, N.; Sorimachi, N.; Shimada, H.; Tagawa, K.; Maruyama, K.; Suzuki, K. (1995). "Muscle-specific calpain, p94, responsible for limb girdle muscular dystrophy type 2A, associates with connectin through IS2, a p94-specific sequence". J. Biol. Chem. 270: 31158–31162. doi:10.1074/jbc.270.52.31158. PMID 8537379.
- ↑ Rey, M.A.; Davies, P.L. (2002). "The protease core of the muscle-specific calpain, p94, undergoes Ca2+-dependent intramolecular autolysis". FEBS Lett. 532 (3): 401–406. doi:10.1016/s0014-5793(02)03722-5. PMID 12482600.
- ↑ García Díaz, B.E.; Gauthier, S.; Davies, P.L. (2006). "Ca2+ dependency of calpain 3 (p94) activation". Biochemistry. 45 (11): 3714–3722. doi:10.1021/bi051917j. PMID 16533054.
- ↑ Ono, Y.; Torii, F.; Ojima, K.; Doi, N.; Yoshioka, K.; Kawabata, Y.; Labeit, D.; Labeit, S.; Suzuki, K.; Abe, K.; Maeda, T.; Sorimachi, H. (2006). "Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system". J. Biol. Chem. 281 (27): 18519–18531. doi:10.1074/jbc.M601029200. PMID 16627476.
External links
- Calpain-3 at the US National Library of Medicine Medical Subject Headings (MeSH)
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