S-methyl-5-thioribose-1-phosphate isomerase
| S-methyl-5-thioribose-1-phosphate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.3.1.23 | ||||||||
| CAS number | 91608-95-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a S-methyl-5-thioribose-1-phosphate isomerase (EC 5.3.1.23) is an enzyme that catalyzes the chemical reaction
- S-methyl-5-thio-alpha-D-ribose 1-phosphate S-methyl-5-thio-D-ribulose 1-phosphate
Hence, this enzyme has one substrate, S-methyl-5-thio-alpha-D-ribose 1-phosphate, and one product, S-methyl-5-thio-D-ribulose 1-phosphate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase. Other names in common use include methylthioribose 1-phosphate isomerase, 1-PMTR isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate, aldose-ketose-isomerase, 1-phospho-5'-S-methylthioribose isomerase, and S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase. This enzyme participates in methionine metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T9K and 1W2W.
References
- RH; Savarese, TM; Dexter, DL; Parks Jr, RE; Trackman, PC; Abeles, RH (1984). "Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma". J. Biol. Chem. 259 (11): 6715–9. PMID 6725268.
- Trackman PC, Abeles RH (1983). "Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities identification of 1-phospho-5-S methylthioribulose". J. Biol. Chem. 258 (11): 6717–20. PMID 6853500.
- Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263 (20): 9598–606. PMID 2838472.