Polyenoic fatty acid isomerase

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).

References

Wise ML, Hamberg M, Gerwick WH (1994). "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina". Biochemistry. 33 (51): 15223–32. doi:10.1021/bi00255a002. PMID 7803384.
Wise ML, Soderstrom K, Murray TF, Gerwick WH (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid". Experientia. 52 (1): 88–92. doi:10.1007/BF01922423. PMID 8575565.
Wise ML, Rossi J, Gerwick WH (1997). "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina". Biochemistry. 36 (10): 2985–92. doi:10.1021/bi962158v. PMID 9062129.
Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH (2002). "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA". Arch. Biochem. Biophys. 401 (1): 11–20. doi:10.1016/S0003-9861(02)00002-4. PMID 12054482.

Isomerases: intramolecular oxidoreductases (EC 5.3)

5.3.1: Aldoses/Ketoses	Triosephosphate isomerase Ribose-5-phosphate isomerase Mannose phosphate isomerase Glucose isomerase

5.3.2: Keto/Enol	Phenylpyruvate tautomerase Oxaloacetate tautomerase

5.3.3: C = C	Steroid D-isomerase Isopentenyl-diphosphate delta isomerase Vinylacetyl-CoA D-isomerase Muconolactone D-isomerase Cholestenol Delta-isomerase (EBP) Methylitaconate D-isomerase Aconitate Delta-isomerase Enoyl CoA isomerase Prostaglandin-A1 Delta-isomerase 5-carboxymethyl-2-hydroxymuconate D-isomerase Isopiperitenone D-isomerase L-dopachrome isomerase Polyenoic fatty acid isomerase

5.3.4: S-S	Protein disulfide-isomerase (PDIA3)

5.3.99: other	Prostaglandin D2 synthase/Prostaglandin-D synthase Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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