HOXD9

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.[5][6][7]

HOXD9
Identifiers
AliasesHOXD9, HOX4, HOX4C, Hox-4.3, Hox-5.2, homeobox D9
External IDsOMIM: 142982 MGI: 96210 HomoloGene: 8409 GeneCards: HOXD9
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q31.1Start176,122,719 bp[1]
End176,124,937 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3235

15438

Ensembl

ENSG00000128709

ENSMUSG00000043342

UniProt

P28356

P28357

RefSeq (mRNA)

NM_014213

NM_013555

RefSeq (protein)

NP_055028

NP_038583

Location (UCSC)Chr 2: 176.12 – 176.12 MbChr 2: 74.7 – 74.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000128709 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043342 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. "Entrez Gene: HOXD9 homeobox D9".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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