FLT4

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.[5][6]

FLT4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFLT4, FLT41, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4, LMPHM1, fms related receptor tyrosine kinase 4, CHTD7
External IDsOMIM: 136352 MGI: 95561 HomoloGene: 7321 GeneCards: FLT4
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q35.3Start180,601,506 bp[1]
End180,649,624 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2324

14257

Ensembl

ENSG00000037280

ENSMUSG00000020357

UniProt

P35916

P35917

RefSeq (mRNA)

NM_002020
NM_182925
NM_001354989

NM_008029

RefSeq (protein)

NP_002011
NP_891555
NP_001341918

NP_032055

Location (UCSC)Chr 5: 180.6 – 180.65 MbChr 11: 49.61 – 49.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.[5]

Interactions

FLT4 has been shown to interact with SHC1.[7][8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000037280 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020357 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FLT4 fms-related tyrosine kinase 4".
  6. Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene". Genomics. 13 (2): 475–8. doi:10.1016/0888-7543(92)90277-Y. PMID 1319394.
  7. Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K (December 1994). "Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors". Oncogene. 9 (12): 3545–55. PMID 7970715.
  8. Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP (January 1999). "Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling". Oncogene. 18 (2): 507–14. doi:10.1038/sj.onc.1202315. PMID 9927207.
  9. Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP (May 1996). "Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase". The Journal of Biological Chemistry. 271 (22): 12956–63. doi:10.1074/jbc.271.22.12956. PMID 8662748.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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