ABCG1

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.[5][6][7] It is a homolog of the well-known Drosophila gene white.

ABCG1
Identifiers
AliasesABCG1, ABC8, WHITE1, ATP binding cassette subfamily G member 1
External IDsOMIM: 603076 MGI: 107704 HomoloGene: 21022 GeneCards: ABCG1
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.3Start42,199,689 bp[1]
End42,297,244 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9619

11307

Ensembl

ENSG00000160179

ENSMUSG00000024030

UniProt

P45844

Q64343

RefSeq (mRNA)

NM_009593

RefSeq (protein)

NP_033723

Location (UCSC)Chr 21: 42.2 – 42.3 MbChr 17: 31.06 – 31.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage, cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000160179 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024030 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen H, Rossier C, Lalioti MD, Lynn A, Chakravarti A, Perrin G, Antonarakis SE (Jul 1996). "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3". American Journal of Human Genetics. 59 (1): 66–75. PMC 1915121. PMID 8659545.
  6. Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer JR, Assmann G, Seedorf U (Aug 2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666)". FEBS Letters. 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. S2CID 22947257.
  7. "Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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