UBE2C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1I7K, 4YII, 5A31

Identifiers

Aliases

UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C

External IDs

MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C

EC number

2.3.2.24

Gene ontology
Molecular function	• transferase activity • nucleotide binding • ubiquitin protein ligase activity • ubiquitin-protein transferase activity • protein binding • ATP binding • ubiquitin conjugating enzyme activity • ubiquitin protein ligase binding
Cellular component	• cytoplasm • cytosol • nucleoplasm • anaphase-promoting complex
Biological process	• free ubiquitin chain polymerization • mitotic nuclear division • ubiquitin-dependent protein catabolic process • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • exit from mitosis • positive regulation of exit from mitosis • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation • protein K11-linked ubiquitination • cell division • protein K48-linked ubiquitination • protein ubiquitination • regulation of mitotic metaphase/anaphase transition • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • cell cycle • anaphase-promoting complex-dependent catabolic process • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of ubiquitin protein ligase activity • protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


11065


68612

Ensembl


ENSG00000175063


ENSMUSG00000001403

UniProt


O00762 Q5TZN3


Q9D1C1

RefSeq (mRNA)

NM_001281741 NM_001281742 NM_007019 NM_181799 NM_181800
NM_181801 NM_181802 NM_181803


NM_026785

RefSeq (protein)

NP_001268670.1 NP_001268671.1 NP_008950.1 NP_861515.1 NP_861516.1
NP_861517.1 NP_008950.1


NP_081061.1

Location (UCSC)

Chr 20: 45.81 – 45.82 Mb

Chr 2: 164.77 – 164.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.^[3]^[4]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
1 2 "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10". J. Biol. Chem. 277 (24): 21913–21. doi:10.1074/jbc.M109398200. PMID 11927573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme". Cancer Res. 63 (14): 4167–73. PMID 12874022.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846.
Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin". Oncogene. 23 (39): 6621–9. doi:10.1038/sj.onc.1207861. PMID 15208666.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas". Br. J. Cancer. 93 (4): 464–71. doi:10.1038/sj.bjc.6602721. PMC 2361574. PMID 16106252.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH". Cancer Genet. Cytogenet. 168 (1): 30–5. doi:10.1016/j.cancergencyto.2005.12.011. PMID 16772118.
Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma". Neoplasia. 8 (12): 1062–71. doi:10.1593/neo.05832. PMC 1783715. PMID 17217624.
Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression". Int. J. Cancer. 121 (1): 33–8. doi:10.1002/ijc.22605. PMID 17354233.

PDB gallery

1i7k: CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES Hsp27 Hsp47 HSP60/GroEL Hsp40/DnaJ A1 A2 A3 B1 B2 B11 B4 B6 B9 C1 C3 C5 C6 C7 C10 C11 C13 C14 C19 Hsp70 1A 1B 1L 2 4 4L 5 6 7 8 9 12A 14 Hsp90 α₁ α₂ β ER TRAP1

Other	Alpha crystallin Clusterin Survival of motor neuron SMN1 SMN2

Protein targeting

Ubiquitin

E1 Ubiquitin-activating enzyme
- UBA1
- UBA2
- UBA3
- UBA5
- UBA6
- UBA7
- ATG7
- NAE1
- SAE1

E2 Ubiquitin-conjugating enzyme
- A
- B
- C
- D1
- D2
- D3
- E1
- E2
- E3
- G1
- G2
- H
- I
- J1
- J2
- K
- L1
- L2
- L3
- L4
- L6
- M
- N
- O
- Q1
- Q2
- R1 (CDC34)
- R2
- S
- V1
- V2
- Z

E3 Ubiquitin ligase
- VHL
- Cullin
- CBL
- MDM2
- FANCL
- UBR1

ATG3
BIRC6
UFC1

Other

Ubiquitin-like modifiers
- SUMO protein
- ISG15
- URM1
- NEDD8
- FAT10
- ATG8
- ATG12
- FUB1
- MUB
- UFM1
- UBL5
Prokaryotic ubiquitin-like protein

This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

UBE2C

References

Further reading