Trimerelysin I
| Trimerelysin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.52 | ||||||||
| CAS number | 151125-16-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Trimerelysin I (EC 3.4.24.52, Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of only two bonds His10-Leu and Ala14-Leu in the insulin B chain
This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).
References
- ↑ Omori-Satoh, T.; Sadahiro, S. (1979). "Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts". Biochim. Biophys. Acta. 580: 392–404. doi:10.1016/0005-2795(79)90151-x. PMID 518906.
- ↑ Yamakawa, Y.; Omori-Satoh, T. (1988). "The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)". Toxicon. 26: 227–231. doi:10.1016/0041-0101(88)90178-x. PMID 3284004.
- ↑ Takeya, H.; Oda, K.; Miyata, T.; Omori-Satoh, T.; Iwanaga, S. (1990). "The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis". J. Biol. Chem. 265: 16068–16073. PMID 2398046.
External links
- Trimerelysin I at the US National Library of Medicine Medical Subject Headings (MeSH)
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