MMP14

MMP14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases MMP14, MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS, matrix metallopeptidase 14
External IDs MGI: 101900 HomoloGene: 21040 GeneCards: MMP14
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

4323

17387

Ensembl

ENSG00000157227

ENSMUSG00000000957

UniProt

P50281

P53690

RefSeq (mRNA)

NM_004995

NM_008608

RefSeq (protein)

NP_004986.1

NP_032634.3

Location (UCSC) Chr 14: 22.84 – 22.85 Mb Chr 14: 54.43 – 54.44 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.[3]

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases.

However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.

"This protein activates MMP2 protein, and this activity may be involved in tumor invasion."[4]

Interactions

MMP14 has been shown to interact with TIMP2.[5]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (Jul 1994). "A matrix metalloproteinase expressed on the surface of invasive tumour cells". Nature. 370 (6484): 61–5. doi:10.1038/370061a0. PMID 8015608.
  4. ↑ "Entrez Gene: MMP14 matrix metallopeptidase 14 (membrane-inserted)".
  5. ↑ Zucker S, Drews M, Conner C, Foda HD, DeClerck YA, Langley KE, Bahou WF, Docherty AJ, Cao J (Jan 1998). "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)". J. Biol. Chem. 273 (2): 1216–22. doi:10.1074/jbc.273.2.1216. PMID 9422789.

Further reading

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