TIMM22

TIMM22

Identifiers

TIMM22, TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast)

External IDs

MGI: 1929742 HomoloGene: 32173 GeneCards: TIMM22

Gene ontology
Molecular function	• mitochondrion targeting sequence binding • protein channel activity
Cellular component	• integral component of membrane • mitochondrial inner membrane • mitochondrial inner membrane protein insertion complex • membrane • mitochondrion
Biological process	• protein transport • protein targeting to mitochondrion • protein import into mitochondrial inner membrane • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


29928


56322


n/a


ENSMUSG00000020843


Q9Y584


Q9CQ85

RefSeq (mRNA)


NM_013337


NM_001291161 NM_019818 NM_023355

RefSeq (protein)


NP_037469.2


NP_001278090.1 NP_062792.2 NP_075844.1

Location (UCSC)

Chr 17: 1 – 1 Mb

Chr 11: 76.41 – 76.42 Mb

PubMed search

^[1]

^[2]

View/Edit Human

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Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the TIMM22 gene.^[3]

See also

References

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel.". Mol. Cell. 9 (2): 363–73. doi:10.1016/S1097-2765(02)00446-X. PMID 11864609.
Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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