Synaptic pharmacology
Synaptic pharmacology is the study of drugs that act on the synapses. It deals with the composition, uses, and effects of drugs that may enhance (receptor) or diminish (blocker) activity at the synapse, which is the junction across which a nerve impulse passes from an axon terminal to a neuron, muscle cell, or gland cell.
A partial list of pharmacological agents that act at synapses follows.
| Channel, Receptor, or Phenomenon | Antagonist or Blocker |
|---|---|
| adenosine | DCPGX, ZM241385, anoxinine |
| AMPA-R | NBQX |
| AMPA-R desensitization | cyclothiazide (CTZ) |
| cannabinoid | AM-251 |
| GABAA | bicuculline,[1] gabazine[1] |
| GABAB | CGP-54626 |
| glycine | strychnine |
| kainate R | .. |
| metabotropic GluR, broad | MCPG,[2] pertussis toxin, NEM |
| muscarinic AChR | atropine, Scopolamine |
| nicotinic AChR | bungarotoxin, curare, DhBe |
| NMDA-R | APV |
References
- 1 2 Ueno S, Bracamontes J, Zorumski C, Weiss DS, Steinbach JH (15 January 1997). "Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor". J. Neurosci. 17 (2): 625–34. PMID 8987785.
- ↑ Frenguelli BG, Potier B, Slater NT, Alford S, Collingridge GL (November 1993). "Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones". Neuropharmacology. 32 (11): 1229–37. doi:10.1016/0028-3908(93)90017-W. PMID 7906405.
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