Steroid 17alpha-monooxygenase

steroid 17-alpha-monooxygenase
Identifiers
EC number 1.14.99.9
CAS number 9029-67-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a steroid 17alpha-monooxygenase (EC 1.14.99.9) is an enzyme that catalyzes the chemical reaction

a steroid + AH2 + O2 a 17alpha-hydroxysteroid + A + H2O

The 3 substrates of this enzyme are steroid, an electron acceptor AH2, and O2, whereas its 3 products are 17alpha-hydroxysteroid, the reduction product A, and H2O.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating). Other names in common use include steroid 17alpha-hydroxylase, cytochrome P-45017alpha, cytochrome P-450 (P-45017alpha,lyase), and 17alpha-hydroxylase-C17,20 lyase. This enzyme participates in c21-steroid hormone metabolism. It has 3 cofactors: NADH, NADPH, and Heme.

References

  1. Lynn, W.S.; Brown, R.H. (1958). "The conversion of progesterone to androgens by testes". J. Biol. Chem. 232 (2): 1015–1030. PMID 13549484.
  2. Yoshida, K.-I.; Oshima, H.; Troen, P. (1980). "Studies of the human testis. XIII. Properties of nicotinamide adenine dinucleotide (reduced form)-linked 17α-hydroxylation". J. Clin. Endocrinol. Metab. 50: 895–899. doi:10.1210/jcem-50-5-895. PMID 6966286.


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