Nitric oxide synthase 2 (inducible)

NOS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Genetically Related Diseases
psoriasis[1]
Targeted by Drug
pimagedine, nitroarginine, 2-amino-4-methylpyridine[2]
Gene ontology Molecular function • FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • NADP binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity Cellular component • cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • nucleus Biological process • positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of vasodilation • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	ENSMUSG00000020826
UniProt	P35228	P29477
RefSeq (mRNA)	NM_000625 NM_153292	NM_010927 NM_001313921 NM_001313922
RefSeq (protein)	NP_000616.3	NP_001300850.1 NP_001300851.1 NP_035057.1
Location (UCSC)	Chr 17: 27.76 – 27.8 Mb	Chr 11: 78.92 – 78.96 Mb
PubMed search	[3]	[4]
Wikidata

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.^[5]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1^[7] and Rac2.^[8]

References

PDB gallery
1nsi: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-BOUND, L-ARG COMPLEX  2nsi: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-FREE, SEITU COMPLEX  4nos: HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE WITH INHIBITOR