Senecionine N-oxygenase

In enzymology, a senecionine N-oxygenase (EC 1.14.13.101) is an enzyme that catalyzes the chemical reaction

senecionine + NADPH + H⁺ + O₂ senecionine N-oxide + NADP⁺ + H₂O

The 4 substrates of this enzyme are senecionine, NADPH, H⁺, and O₂, whereas its 3 products are senecionine N-oxide, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming). Other names in common use include senecionine monooxygenase (N-oxide-forming), and SNO.

References

• Lindigkeit R, Biller A, Buch M, Schiebel HM, Boppre M, Hartmann T (1997). "The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids". Eur. J. Biochem. 245 (3): 626–36. doi:10.1111/j.1432-1033.1997.00626.x. PMID 9182998. 
• Naumann C, Hartmann T, Ober D (2002). "Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6085–90. doi:10.1073/pnas.082674499. PMC 122906. PMID 11972041.