Segmental duplication

Segmental duplications (SDs) are segments of DNA with near-identical sequence.[1]

Segmental duplications give rise to low copy repeats (LCRs) and are believed to have played a role in creating new primate genes as reflected in human genetic variation. In humans, chromosomes Y and 22 have the greatest proportion of SDs: 50.4% and 11.9% respectively.[2]

Detection method

The two widely accepted methods for SD detection are whole genome assembly comparison (WGAC) and whole genome shotgun sequence detection (WSSD).

See also

References

  1. Genome-wide detection of segmental duplications
  2. Bailey, Jeffrey A.; Eichler, EE (2006). "Primate segmental duplications: crucibles of evolution, diversity and disease". Nature Reviews Genetics. 7 (7): 552–64. doi:10.1038/nrg1895. PMID 16770338.


This article is issued from Wikipedia - version of the 5/5/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.