Phenacaine

Phenacaine
Names

IUPAC name (1E)-N,N′-Bis(4-ethoxyphenyl)ethanimidamide
Identifiers
CAS Number	101-93-9
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL127123
ChemSpider	7307
PubChem	7588
UNII	V3M4D317W8^Y
InChI InChI=1S/C18H22N2O2/c1-4-21-17-10-6-15(7-11-17)19-14(3)20-16-8-12-18(13-9-16)22-5-2/h6-13H,4-5H2,1-3H3,(H,19,20)
SMILES O(c1ccc(cc1)N\C(=N\c2ccc(OCC)cc2)C)CC
Properties
Chemical formula	C₁₈H₂₂N₂O₂
Molar mass	298.39 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Phenacaine, also known as holocaine,^[1] is a local anesthetic. It is the only anesthetic other than cocaine that is approved for ophthalmic use.^[2]

References

↑ "Holocaine Hydrochloride".
↑ Merck Index, 1985

Local anesthetics (primarily sodium channel blockers) (N01B)

Esters by acid

Aminobenzoic	Benzocaine Butacaine Butamben Chloroprocaine Dimethocaine Lucaine Meprylcaine Metabutethamine Metabutoxycaine Nitracaine Orthocaine Propoxycaine Procaine (Novocaine) Proxymetacaine Risocaine Tetracaine

Benzoic	Amylocaine Cocaine Cyclomethycaine α-Eucaine β-Eucaine Hexylcaine Isobucaine Piperocaine

ArCO2- (not para-amino or Ph)	Amoproxan (3,4,5-Trimethoxybenzoyl) 3-(p-Fluorobenzoyloxy)tropane

Amides

Articaine
Bupivacaine^# / Levobupivacaine / Ropivacaine
Butanilicaine
Carticaine
Dibucaine
Etidocaine
Lidocaine^#
Mepivacaine
Prilocaine
Trimecaine

Combinations

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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