PRPF4
U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene.[3][4][5]
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][5]
References
Further reading
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- Horowitz DS, Krainer AR (1997). "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.". Genes Dev. 11 (1): 139–51. doi:10.1101/gad.11.1.139. PMID 9000057.
- Wang A, Forman-Kay J, Luo Y, et al. (1997). "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome.". Hum. Mol. Genet. 6 (12): 2117–26. doi:10.1093/hmg/6.12.2117. PMID 9328476.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33.". Genomics. 48 (2): 273–5. doi:10.1006/geno.1997.5181. PMID 9521884.
- Kojima T, Zama T, Wada K, et al. (2001). "Cloning of human PRP4 reveals interaction with Clk1.". J. Biol. Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
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- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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- Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.". RNA. 12 (7): 1418–30. doi:10.1261/rna.55406. PMC 1484429. PMID 16723661.
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