PRMT3

PRMT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PRMT3, HRMT1L3, protein arginine methyltransferase 3
External IDs MGI: 1919224 HomoloGene: 24255 GeneCards: PRMT3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

10196

71974

Ensembl

ENSG00000185238

ENSMUSG00000030505

UniProt

O60678

Q922H1

RefSeq (mRNA)

NM_001145166
NM_001145167
NM_005788

NM_133740

RefSeq (protein)

NP_005779.1

NP_598501.1

Location (UCSC) Chr 11: 20.39 – 20.51 Mb Chr 7: 49.78 – 49.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.[3][4]

Model organisms

Model organisms have been used in the study of PRMT3 function. A conditional knockout mouse line, called Prmt3tm1a(EUCOMM)Wtsi[13][14] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][18] Twenty seven tests were carried out on mutant mice and seven significant abnormalities were observed.[11] Fewer than predicted homozygous mutant mice survived until weaning due to hydrocephaly. The remaining tests were carried out on both heterozygous and homozygous mutant adult mice. Male heterzygous mice had a decreased respiratory quotient. Homozygous females had decreased body weight, length and bone mineral density. Homozygous males had abnormal peripheral blood lymphocyte counts and homozygotes of both sex had eye abnormalities.[11]

Interactions

PRMT3 has been shown to interact with RPS2.[19]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Tang J, Gary JD, Clarke S, Herschman HR (Aug 1998). "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation". J Biol Chem. 273 (27): 16935–45. doi:10.1074/jbc.273.27.16935. PMID 9642256.
  4. "Entrez Gene: PRMT3 protein arginine methyltransferase 3".
  5. "Body weight data for Prmt3". Wellcome Trust Sanger Institute.
  6. "Indirect calorimetry data for Prmt3". Wellcome Trust Sanger Institute.
  7. "DEXA data for Prmt3". Wellcome Trust Sanger Institute.
  8. "Eye morphology data for Prmt3". Wellcome Trust Sanger Institute.
  9. "Salmonella infection data for Prmt3". Wellcome Trust Sanger Institute.
  10. "Citrobacter infection data for Prmt3". Wellcome Trust Sanger Institute.
  11. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  12. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  13. "International Knockout Mouse Consortium".
  14. "Mouse Genome Informatics".
  15. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  16. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  17. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  18. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353.
  19. Choi, Seeyoung; Jung Cho-Rok; Kim Jin-Young; Im Dong-Soo (Sep 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochim. Biophys. Acta. Netherlands. 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. ISSN 0006-3002. PMID 18573314.

Further reading


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