Nicotinyl alcohol

Nicotinyl alcohol
Clinical data

AHFS/Drugs.com	Monograph
ATC code	C10AD05 (WHO) C04AC02 (WHO)
Identifiers
IUPAC name (Pyridin-3-yl)methanol
CAS Number	100-55-0^Y
PubChem (CID)	7510
ChemSpider	7229^N
UNII	9TF312056Y^N
ECHA InfoCard	100.002.604
Chemical and physical data
Formula	C₆H₇NO
Molar mass	109.126 g/mol
3D model (Jmol)	Interactive image
SMILES OCc1cccnc1
InChI InChI=1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2^N
^NY (what is this?) (verify)

Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.^[1]

It appears as a crystal that dissolves in water and alcohol with ease, also soluble in eter; melting range 147-148º.

Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper torax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans,^[2] Raynaud's disease,^[3] thromboangiitis obliterans (Buerger's disease),^[4] arterial embolism, chilblains or migraine associated with vascular spasm.

Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in syntoms related to intermittent claudication,^[5] ulcer healing and others.^[6]

References

↑ "Ronicol Retard". Medical Dictionary Online. 2012. Retrieved July 27, 2012.
↑ Richter IH, Fogel M, Fabricant H (1951). "An evaluation of roniacol tartrate in arteriosclerosis obliterans". New York State Journal of Medicine. 51 (10): 1303–4. PMID 14843421.
↑ http://www.theodora.com/medical_dictionary/nicotine_nitrocellulose.html
↑ http://es.slideshare.net/ravinarwal/buergers-disease-by-dr-ravinder-narwal Page 18
↑ Gillhespy, RO (1957). "Nicotinyl Alcohol Tartrate in Intermittent Claudication". British Medical Journal. 18 (2): 207–208. PMID 1974214.
↑ Fisher MM, Tebrock HW (1953). "Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations". New York State Journal of Medicine. 53 (1): 65–8. PMID 13025721.

Lipid modifying agents (C10)

GI tract

Cholesterol absorption inhibitors, NPC1L1	Ezetimibe SCH-48461

Bile acid sequestrants/resins (LDL)	Colestyramine Colestipol Colestilan Colextran Colesevelam

Liver

Statins (HMG-CoA reductase, LDL)	Simvastatin^# Atorvastatin Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Cerivastatin^‡

Niacin and derivatives (HDL and LDL)	Niceritrol Niacin Nicofuranose Aluminium nicotinate Nicotinyl alcohol Acipimox

MTTP inhibitors (VLDL)	Dirlotapide Lomitapide Mitratapide

Blood vessels

Fibrates (PPAR)	Clofibrate^‡ Bezafibrate Aluminium clofibrate Gemfibrozil Fenofibrate Simfibrate Ronifibrate Ciprofibrate Etofibrate Clofibride Clinofibrate

CETP inhibitors (HDL)	Anacetrapib^† Dalcetrapib^§ Evacetrapib^§ Torcetrapib^§

Combinations

Other

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Peripheral vasodilators (C04)

Phenylethanolamine derivatives	Isoxsuprine Buphenine Bamethan

Alpha blockers	Non-selective Tolazoline Phentolamine Selective α₁-blockers Alfuzosin Doxazosin Prazosin Silodosin Tamsulosin Terazosin

Niacin and derivatives	Niacin Nicotinyl alcohol Inositol nicotinate Ciclonicate

Purine derivatives	Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate

Ergot alkaloids	Ergoloid Nicergoline Dihydroergocristine

Other peripheral vasodilators	Cyclandelate Phenoxybenzamine Vincamine Moxisylyte Bencyclane Vinburnine Sulcotidil Buflomedil Naftidrofuryl Butalamine Visnadine Cetiedil Cinepazide Ifenprodil Azapetine Fasudil

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