N-acetyltransferase 1

NAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases NAT1, AAC1, MNAT, NAT-1, NATI, N-acetyltransferase 1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
External IDs MGI: 109201 HomoloGene: 37329 GeneCards: NAT1
Orthologs
Species Human Mouse
Entrez

9

17961

Ensembl

ENSG00000171428

ENSMUSG00000051147

UniProt

P18440
Q400J6

P50295

RefSeq (mRNA)

NM_001168577
NM_010874

RefSeq (protein)

NP_001162049.1
NP_035004.1

Location (UCSC) Chr 8: 18.17 – 18.22 Mb Chr 8: 67.49 – 67.5 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.[3]

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].[3]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: N-acetyltransferase 1 (arylamine N-acetyltransferase)". Retrieved 2012-01-27.

Further reading

  • Gubin, A. N.; Njoroge, J. M.; Bouffard, G. G.; Miller, J. L. (1999). "Gene Expression in Proliferating Human Erythroid Cells". Genomics. 59 (2): 168–177. doi:10.1006/geno.1999.5855. PMID 10409428. 
  • Smelt, V. A.; Upton, A.; Adjaye, J.; Payton, M. A.; Boukouvala, S.; Johnson, N.; Mardon, H. J.; Sim, E. (2000). "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics. 9 (7): 1101–1107. doi:10.1093/hmg/9.7.1101. PMID 10767335. 
  • Brockton, N.; Little, J.; Sharp, L.; Cotton, S. C. (2000). "N-acetyltransferase polymorphisms and colorectal cancer: A HuGE review". American Journal of Epidemiology. 151 (9): 846–861. doi:10.1093/oxfordjournals.aje.a010289. PMID 10791558. 
  • Lo-Guidice, J. M.; Allorge, D.; Chevalier, D.; Debuysère, H.; Fazio, F.; Lafitte, L. J.; Broly, F. (2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics. 10 (4): 293–300. doi:10.1097/00008571-200006000-00003. PMID 10862520. 
  • De León, J. H.; Vatsis, K. P.; Weber, W. W. (2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology. 58 (2): 288–299. PMID 10908296. 
  • Yu, M. W.; Pai, C. I.; Yang, S. Y.; Hsiao, T. J.; Chang, H. C.; Lin, S. M.; Liaw, Y. F.; Chen, P. J.; Chen, C. J. (2000). "Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: Impact of smoking on risk". Gut. 47 (5): 703–709. doi:10.1136/gut.47.5.703. PMC 1728099Freely accessible. PMID 11034589. 
  • Wikman, H.; Thiel, S.; Jäger, B.; Schmezer, P.; Spiegelhalder, B.; Edler, L.; Dienemann, H.; Kayser, K.; Schulz, V.; Drings, P.; Bartsch, H.; Risch, A. (2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics. 11 (2): 157–168. doi:10.1097/00008571-200103000-00006. PMID 11266080. 
  • Krajinovic, M.; Ghadirian, P.; Richer, C.; Sinnett, H.; Gandini, S.; Perret, C.; Lacroix, A.; Labuda, D.; Sinnett, D. (2001). "Genetic susceptibility to breast cancer in French-Canadians: Role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer. 92 (2): 220–225. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H. PMID 11291049. 
  • Sekine, A.; Saito, A.; Iida, Y.; Mitsunobu, S.; Higuchi, S.; Harigae, Y.; Nakamura, S. (2001). "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1 , NAT2 , AANAT , ARD1 , and L1CAM in the Japanese population". Journal of Human Genetics. 46 (6): 314–319. doi:10.1007/s100380170065. PMID 11393533. 
  • Butler, W. J.; Ryan, P.; Roberts-Thomson, I. C. (June 2001). "Metabolic genotypes and risk for colorectal cancer". J. Gastroenterol. Hepatol. 16 (6): 631–635. doi:10.1046/j.1440-1746.2001.02501.x. PMID 11422615. 


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