N-acetyltransferase

N-acetyltransferase is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to arylamines.^[1]^[2] They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.

Examples

The following is a list of human genes that encode N-acetyltransferase enzymes:

Symbol	Name
AANAT	aralkylamine N-acetyltransferase
ARD1A	ARD1 homolog A, N-acetyltransferase (S. cerevisiae)
GNPNAT1	glucosamine-phosphate N-acetyltransferase 1
HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase
MAK10	MAK10 homolog, amino-acid N-acetyltransferase subunit (S. cerevisiae)
NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)
NAT5	N-acetyltransferase 5 (GCN5-related, putative)
NAT6	N-acetyltransferase 6 (GCN5-related)
NAT8	N-acetyltransferase 8 (GCN5-related, putative)
NAT8L	N-acetyltransferase 8-like (GCN5-related, putative)
NAT9	N-acetyltransferase 9 (GCN5-related, putative)
NAT10	N-acetyltransferase 10 (GCN5-related)
NAT11	N-acetyltransferase 11 (GCN5-related, putative)
NAT12	N-acetyltransferase 12 (GCN5-related, putative)
NAT13	N-acetyltransferase 13 (GCN5-related)
NAT14	N-acetyltransferase 14 (GCN5-related, putative)
NAT15	N-acetyltransferase 15 (GCN5-related, putative)

↑ Evans DA (1989). "N-acetyltransferase". Pharmacology & Therapeutics. 42 (2): 157–234. doi:10.1016/0163-7258(89)90036-3. PMID 2664821.
↑ Ma Y, Ghoshdastider U, Wang J, Ye W, Dötsch V, Filipek S, Bernhard F, Wang X (2012). "Cell-free expression of human glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening". Protein Expr. Purif. 86 (2): 120–6. doi:10.1016/j.pep.2012.09.011. PMID 23036358.

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII

2.3.3: converted into alkyl on transfer	Citrate synthase ATP citrate lyase HMG-CoA synthase Malate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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