(+)-Menthofuran synthase
| (+)-Menthofuran synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.104 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
(+)-Menthofuran synthase (EC 1.14.13.104, menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction
- (+)-pulegone + NADPH + H+ + O2 (+)-menthofuran + NADP+ + H2O
Menthofuran synthase is a heme-thiolate protein (P-450).
References
- ↑ Bertea, C.M.; Schalk, M.; Karp, F.; Maffei, M.; Croteau, R. (2001). "Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene". Arch. Biochem. Biophys. 390 (2): 279–286. doi:10.1006/abbi.2001.2378. PMID 11396930.
- ↑ Mahmoud, S.S.; Croteau, R.B. (2003). "Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase". Proc. Natl. Acad. Sci. USA. 100 (24): 14481–14486. doi:10.1073/pnas.2436325100. PMC 283617
. PMID 14623962.
External links
- ( )-menthofuran synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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