FANC proteins

FANC proteins are a group of proteins associated with Fanconi anemia.^[1]^[2]^[3]

They are involved in DNA replication and damage response.^[4]

Components include:

References

↑ FANC Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
↑ Naim V, Rosselli F (June 2009). "The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities". Nat. Cell Biol. 11 (6): 761–8. doi:10.1038/ncb1883. PMID 19465921.
↑ Hans D. Ochs; C. I. Edvard Smith; Jennifer Puck (2007). Primary immunodeficiency diseases: a molecular and genetic approach. Oxford University Press US. pp. 431–. ISBN 978-0-19-514774-2. Retrieved 21 December 2010.
↑ Naim V, Rosselli F (September 2009). "The FANC pathway and mitosis: a replication legacy". Cell Cycle. 8 (18): 2907–11. doi:10.4161/cc.8.18.9538. PMID 19729998.

DNA repair

Excision repair	Base excision repair/AP site DNA glycosylase Uracil-DNA glycosylase Poly ADP ribose polymerase Nucleotide excision repair/ERCC XPA XPB XPC XPD/ERCC2 XPE/DDB1 XPF/DDB1 XPG/ERCC5 ERCC1 RPA RAD23A RAD23B Excinuclease DNA mismatch repair MLH1 MSH2

Other forms of repair	Transcription-coupled repair ERCC6 ERCC8 Homology directed repair Non-homologous end joining Ku Microhomology-mediated end joining Postreplication repair Photolyase CRY1 CRY2

Other/ungrouped proteins	Ogt PcrA Proliferating Cell Nuclear Antigen Homologous recombination RecA/RAD51 Sgs1 Slx4

Regulation	SOS box SOS response

Other/ungrouped	8-Oxoguanine Adaptive response Meiotic recombination checkpoint RecF pathway DNA helicase: BLM WRN FANC proteins: core protein complex FANCA FANCB FANCC FANCE FANCF FANCG FANCL FANCM FANCD1 FANCD2 FANCI FANCJ FANCN

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