EIF2C2

AGO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LUC, 3LUD, 3LUG, 3LUH, 3LUJ, 3LUK, 3QX8, 3QX9, 4F3T, 4OLA, 4OLB, 4W5N, 4W5O, 4W5Q, 4W5R, 4W5T, 4Z4C, 4Z4D, 4Z4E, 4Z4F, 4Z4G, 4Z4H, 4Z4I, 5JS1, 5JS2
Identifiers
Aliases	AGO2, EIF2C2, Q10, argonaute 2, RISC catalytic component
External IDs	MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2
Gene ontology Molecular function • protein binding • protein C-terminus binding • metal ion binding • poly(A) RNA binding • nuclease activity • endoribonuclease activity, cleaving miRNA-paired mRNA • RNA 7-methylguanosine cap binding • hydrolase activity • translation initiation factor activity • endoribonuclease activity, producing 5'-phosphomonoesters • endonuclease activity • RNA binding • endoribonuclease activity, cleaving siRNA-paired mRNA • siRNA binding • core promoter binding • single-stranded RNA binding • double-stranded RNA binding • RNA polymerase II core binding • nucleic acid binding • mRNA binding • miRNA binding • endoribonuclease activity Cellular component • cytoplasm • nucleoplasm • polysome • micro-ribonucleoprotein complex • mRNA cap binding complex • membrane • cytoplasmic mRNA processing body • dendrite • intracellular ribonucleoprotein complex • RISC-loading complex • RISC complex • cytosol • nucleus Biological process • negative regulation of translational initiation • mRNA cleavage involved in gene silencing by miRNA • RNA secondary structure unwinding • phosphatidylinositol-mediated signaling • miRNA metabolic process • transcription, DNA-templated • regulation of translation • posttranscriptional gene silencing by RNA • translation • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • positive regulation of gene expression • production of miRNAs involved in gene silencing by miRNA • miRNA loading onto RISC involved in gene silencing by miRNA • mRNA cleavage involved in gene silencing by siRNA • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • pre-miRNA processing • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • miRNA mediated inhibition of translation • post-embryonic development • siRNA loading onto RISC involved in RNA interference • gene silencing by RNA • RNA phosphodiester bond hydrolysis, endonucleolytic • translational initiation • Wnt signaling pathway, calcium modulating pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27161	239528
Ensembl	ENSG00000123908	ENSMUSG00000036698
UniProt	Q9UKV8	Q8CJG0
RefSeq (mRNA)	NM_001164623 NM_012154	NM_153178
RefSeq (protein)	NP_001158095.1 NP_036286.2	NP_694818.3
Location (UCSC)	Chr 8: 140.52 – 140.64 Mb	Chr 15: 73.1 – 73.18 Mb
PubMed search	[1]	[2]
Wikidata

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.^[3][4][5]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.^[5]

Interactions

EIF2C2 has been shown to interact with

• DDX20,^[6][7]
• DICER1,^[7][8]
• FMRP, FXR1P, FXR2P,^[9] and
• TNRC6B.^[10]

References

Further reading