DDX20

DDX20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases DDX20, DP103, GEMIN3, DEAD-box helicase 20
External IDs MGI: 1858415 HomoloGene: 5214 GeneCards: DDX20
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

11218

53975

Ensembl

ENSG00000064703

ENSMUSG00000027905

UniProt

Q9UHI6

Q9JJY4

RefSeq (mRNA)

NM_007204

NM_017397

RefSeq (protein)

NP_009135.4

NP_059093.3

Location (UCSC) Chr 1: 111.76 – 111.77 Mb Chr 3: 105.68 – 105.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.[3][4]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neuron (SMN) complex.[4] This DEAD box protein is one of the gem-associated proteins (GEMIN3) that interacts directly with SMN.[5] SMN is the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.[4]

Interactions

DDX20 has been shown to interact with:

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Grundhoff AT, Kremmer E, Türeci O, Glieden A, Gindorf C, Atz J, Mueller-Lantzsch N, Schubach WH, Grässer FA (July 1999). "Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C". J Biol Chem. 274 (27): 19136–44. doi:10.1074/jbc.274.27.19136. PMID 10383418.
  4. 1 2 3 "Entrez Gene: DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20".
  5. ↑ Seng, CO; Magee, C; Young, PJ; Lorson, CL; Allen, JP (15 April 2015). "The SMN structure reveals its crucial role in snRNP assembly.". Human Molecular Genetics. 24 (8): 2138–46. doi:10.1093/hmg/ddu734. PMID 25561692.
  6. 1 2 3 4 5 Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365Freely accessible. PMID 11914277.
  7. ↑ Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA. 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934Freely accessible. PMID 14970384.
  8. 1 2 Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731.
  9. ↑ Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312Freely accessible. PMID 10725331.
  10. ↑ Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
  11. 1 2 3 4 5 6 7 8 9 10 Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095Freely accessible. PMID 10601333.
  12. ↑ Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426.

Further reading

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