Cis-abienol synthase

Cis-abienol synthase (EC 4.2.3.140, Z-abienol synthase, CAS, ABS) is an enzyme with systematic name (13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol forming).^[1]^[2] This enzyme catalyses the following chemical reaction

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate

\rightleftharpoons

cis-abienol + diphosphate

This enzyme is isolated from the plants Abies balsamea (balsam fir) and Nicotiana tabacum (tobacco).

References

↑ Zerbe, P.; Chiang, A.; Yuen, M.; Hamberger, B.; Hamberger, B.; Draper, J.A.; Britton, R.; Bohlmann, J. (2012). "Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production". J. Biol. Chem. 287: 12121–12131. doi:10.1074/jbc.m111.317669. PMID 22337889.
↑ Sallaud, C.; Giacalone, C.; Topfer, R.; Goepfert, S.; Bakaher, N.; Rosti, S.; Tissier, A. (2012). "Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes". Plant J. 72: 1–17. doi:10.1111/j.1365-313x.2012.05068.x. PMID 22672125.

Cis-abienol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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