Bisdisulizole disodium

Bisdisulizole disodium
Names


IUPAC name disodium 2,2'-(1,4-phenylene)bis(6-sulfo-1H-benzimidazole-4-sulfonate)
Identifiers
CAS Number	180898-37-7^Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL2111085^N
ChemSpider	9333274^Y
ECHA InfoCard	100.121.951
PubChem	11158166
InChI InChI=1S/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2^Y Key: GLCJMPWWQKKJQZ-UHFFFAOYSA-L^Y InChI=1/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2 Key: GLCJMPWWQKKJQZ-NUQVWONBAQ
SMILES [Na+].[Na+].O=S(=O)(O)c1cc2nc(nc2c(c1)S([O-])(=O)=O)c5ccc(c4nc3c(cc(cc3n4)S(=O)(=O)O)S([O-])(=O)=O)cc5
Properties
Chemical formula	C₂₀H₁₂N₄Na₂O₁₂S₄
Molar mass	674.55 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Bisdisulizole disodium (INN^[1]/USAN,^[2] trade name Neo Heliopan AP, INCI disodium phenyl dibenzimidazole tetrasulfonate) is a water-soluble organic compound which is added to sunscreens to absorb UVA rays. It is marketed by Symrise.

Bisdisulizole disodium is not approved in the United States by the FDA, but it has been approved in the European Union since the year 2000^[3] and other parts of the world.^[4]^[5]

References

↑ http://ec.europa.eu/enterprise/cosmetics/cosing/index.cfm?fuseaction=search.detailsPDF&id=75792
↑ "Statement on a nonproprietary name adopted by the USAN Council: Bisdisulizole disodium" (PDF). American Medical Association. April 4, 2006. Retrieved 2008-01-08.
↑ Osstervalder U, Luther H, Herzog B (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter". Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (in German). 44 (5): 463–70. doi:10.1007/s001030170019.
↑ "10. Sunscreens" (PDF). Australian regulatory guidelines for OTC medicines. Commonwealth Department of Health and Ageing, Therapeutic Goods Administration. July 1, 2003. p. 14. Retrieved 2008-01-08.
↑ "Symrise UV protection products" (PDF). Symrise. Retrieved 2008-08-10.

Sunscreening agents approved by the US FDA or other agencies

UVA: 400–315 nm UVB: 315–290 nm chemical agents unless otherwise noted

UVA filters	Avobenzone (Parsol 1789) Bisdisulizole disodium (Neo Heliopan AP) Diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) Ecamsule (Mexoryl SX) Menthyl anthranilate

UVB filters	Amiloxate 4-Aminobenzoic acid (PABA) Cinoxate Ethylhexyl triazone (Uvinul T 150) Homosalate 4-Methylbenzylidene camphor (Parsol 5000) Octyl methoxycinnamate (Octinoxate) Octyl salicylate (Octisalate) Padimate O (Escalol 507) Phenylbenzimidazole sulfonic acid (Ensulizole) Polysilicone-15 (Parsol SLX) Trolamine salicylate

UVA+UVB filters	Bemotrizinol (Tinosorb S) Benzophenones 1–12 Dioxybenzone Drometrizole trisiloxane (Mexoryl XL) Iscotrizinol (Uvasorb HEB) Octocrylene Oxybenzone (Eusolex 4360) Sulisobenzone hybrid (chemical/physical): Bisoctrizole (Tinosorb M) physical: Titanium dioxide Zinc oxide

See also: Photoprotection Potential health risks of sunscreen Sun protective clothing Sun tanning Sunburn

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