Amidohydrolase

Amidohydrolases (or amidases) are a type of hydrolase that acts upon amide bonds.

They are categorized under EC number EC 3.5.1 and 3.5.2.

Examples include:

The amidohydrolase superfamily is a large protein family of more than 20,000 members with diverse chemistry and physiologic roles. Due to its complexity and size, the amidohyrolase superfamily is being used by the Enzyme Function Initiative (EFI) for developing a large-scale strategy for functional assignment of unknown proteins.

External links

Amidohydrolases at the US National Library of Medicine Medical Subject Headings (MeSH)
CRISP Thesaurus 00000306

Amidohydrolase Overview from the EFI

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)

3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin

3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase

3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase

3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase

3.5.5: Nitriles/ Aminohydrolases	Nitrilase

3.5.99: Other	Riboflavinase Thiaminase II

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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Amidohydrolase

See also

External links