Orotate reductase (NADPH)

In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction

(S)-dihydroorotate + NADP+ orotate + NADPH + H+
orotate reductase (NADPH)
Identifiers
EC number1.3.1.15
CAS number37255-27-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP+, whereas its 3 products are orotate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP+ oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.

References

    • Taylor WH, Taylor ML, Eames DF (1966). "Two functionally different dihydroorotic dehydrogenases in bacteria". J. Bacteriol. 91 (6): 2251–6. PMC 316202. PMID 4380263.
    • Ukada S, Vennesland B (1962). "Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase". J. Biol. Chem. 237: 2018–2024. PMID 13923427.


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