Malate dehydrogenase (NAD(P)+)
Malate dehydrogenase (NAD(P)+) (EC 1.1.1.299, MdH II, NAD(P)+-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- (S)-malate + NAD(P)+ oxaloacetate + NAD(P)H + H+
| Malate dehydrogenase (NAD(P)+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.299 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).
References
- Thompson H, Tersteegen A, Thauer RK, Hedderich R (July 1998). "Two malate dehydrogenases in Methanobacterium thermoautotrophicum". Archives of Microbiology. 170 (1): 38–42. doi:10.1007/s002030050612. PMID 9639601.
External links
- Malate+dehydrogenase+(NAD(P)+) at the US National Library of Medicine Medical Subject Headings (MeSH)
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