Isopropanol dehydrogenase (NADP+)

In enzymology, an isopropanol dehydrogenase (NADP+) (EC 1.1.1.80) is an enzyme that catalyzes the chemical reaction

propan-2-ol + NADP+ acetone + NADPH + H+
isopropanol dehydrogenase (NADP+)
Identifiers
EC number1.1.1.80
CAS number37250-18-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are propan-2-ol and NADP+, whereas its 3 products are acetone, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is propan-2-ol:NADP+ oxidoreductase. This enzyme is also called isopropanol dehydrogenase (NADP+). This enzyme participates in propanoate metabolism.

References

    • Hoshino K (1960). "Organism producing isopropanol from acetone. V. Enzymological [studies] on the oxidation-reduction of Lactobacillus brevis var. hofuensis". Nippon Nogeikagaku Kaishi (in Japanese). 34: 608–615. doi:10.1271/nogeikagaku1924.34.7_608.
    • Hoshino K, Udagawa K (1960). "Organism producing isopropanol from acetone. VI. Isopropanol dehydrogenase and alcohol dehydrogenase of Lactobacillus brevis var. hofuensis". Nippon Nogeikagaku Kaishi (in Japanese). 34: 616–619. doi:10.1271/nogeikagaku1924.34.7_616.


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