Gluconate 2-dehydrogenase

In enzymology, a gluconate 2-dehydrogenase (EC 1.1.1.215) is an enzyme that catalyzes the chemical reaction

D-gluconate + NADP+ 2-dehydro-D-gluconate + NADPH + H+
gluconate 2-dehydrogenase
Identifiers
EC number1.1.1.215
CAS number68417-42-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are D-gluconate and NADP+, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP+ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.

References

    • Ameyama M (1978). "Crystalline 2-ketogluconate reductase from Acetobacter ascendens, the second instance of crystalline enzyme in genus Acetobacter". Agric. Biol. Chem. 42 (11): 2057–2062. doi:10.1271/bbb1961.42.2057.
    • Chiyonobu T, Shinagawa E, Adachi O, Ameyama M (1976). "Purification, crystallization and properties of 2-ketogluconate reductase from Acetobacter rancens". Agric. Biol. Chem. 40: 175–184. doi:10.1271/bbb1961.40.175.


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