EHD1

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene[4] belonging to the EHD protein family.

EHD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEHD1, H-PAST, HPAST1, PAST, PAST1, EH domain containing 1
External IDsOMIM: 605888 MGI: 1341878 HomoloGene: 81678 GeneCards: EHD1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start64,851,642 bp[1]
End64,888,296 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10938

13660

Ensembl

ENSG00000110047

ENSMUSG00000024772

UniProt

Q9H4M9

Q9WVK4

RefSeq (mRNA)

NM_001282444
NM_001282445
NM_006795

NM_010119

RefSeq (protein)

NP_001269373
NP_001269374
NP_006786

NP_034249

Location (UCSC)Chr 11: 64.85 – 64.89 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.[4]

Interactions

EHD1 has been shown to interact with Insulin-like growth factor 1 receptor[5] and SNAP29.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000110047 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: EHD1 EH-domain containing 1".
  5. Rotem-Yehudar, R; Galperin E; Horowitz M (Aug 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. United States. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532.

Further reading


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