Diethylthiambutene
Diethylthiambutene (Thiambutene, Themalon, Diethibutin, N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine) is an opioid analgesic drug developed in the 1950s[1] which was mainly used as an anesthetic in veterinary medicine and continues, along with the other two thiambutenes dimethylthiambutene and ethylmethylthiambutene to be used for this purpose, particularly in Japan.[2][3] It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available. It is listed under Schedule I of the US Controlled Substances Act as a Narcotic and has an ACSCN of 9616 with zero annual manufacturing quota as of 2013.
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| Formula | C16H21NS2 |
| Molar mass | 291.47 g·mol−1 |
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| Melting point | 152 to 153 °C (306 to 307 °F) |
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References
- Beckett AH, Casy AF, Harper NJ, Phillips PM (November 1956). "Analgesics and their antagonists: some steric and chemical considerations. II. The influence of the basic group on physico-chemical properties and the activity of methadone and thiambutene-type compounds". The Journal of Pharmacy and Pharmacology. 8 (11): 860–73. doi:10.1111/j.2042-7158.1956.tb12216.x. PMID 13368083. S2CID 41750428.
- Hayes MJ (November 1968). "The use of thiambutene hydrochloride". The Veterinary Record. 83 (20): 528. doi:10.1136/vr.83.20.528-a. PMID 5694027. S2CID 45820838.
- Harbison WD, Slocombe RF, Watts SJ, Stewart GA (December 1974). "Thiambutene and acepromazine as analgesic and preanaesthetic agents in horses and sheep". Australian Veterinary Journal. 50 (12): 543–6. doi:10.1111/j.1751-0813.1974.tb14073.x. PMID 4156466.
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