4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase

In enzymology, a 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase (EC 5.3.1.17) is an enzyme that catalyzes the chemical reaction

4-deoxy-L-threo-5-hexosulose uronate 3-deoxy-D-glycero-2,5-hexodiulosonate
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
Identifiers
EC number5.3.1.17
CAS number37318-44-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, 4-deoxy-L-threo-5-hexosulose uronate, and one product, 3-deoxy-D-glycero-2,5-hexodiulosonate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase. This enzyme is also called 4-deoxy-L-threo-5-hexulose uronate isomerase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X8M, 1XRU, and 1YWK.

References

    • Preiss J (1966). "4-Deoxy-L-threo-5-hexosulose uronic acid isomerase". Carbohydrate Metabolism. Methods in Enzymology. 9. pp. 602–604. doi:10.1016/0076-6879(66)09121-3. ISBN 978-0-12-181809-8.


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