2-oxoglutarate carboxylase

In enzymology, a 2-oxoglutarate carboxylase (EC 6.4.1.7) is an enzyme that catalyzes the chemical reaction

ATP + 2-oxoglutarate + HCO3- ADP + phosphate + oxalosuccinate
2-oxoglutarate carboxylase
Identifiers
EC number6.4.1.7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The 3 substrates of this enzyme are ATP, 2-oxoglutarate, and HCO3-, whereas its 3 products are ADP, phosphate, and oxalosuccinate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is '. Other names in common use include oxalosuccinate synthetase', carboxylating factor for ICDH (incorrect), CFI, and OGC.

References

    • Aoshima M, Ishii M, Igarashi Y (2004). "A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 51 (3): 791–8. doi:10.1046/j.1365-2958.2003.03863.x. PMID 14731279.
    • Aoshima M, Igarashi Y (2006). "A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 62 (3): 748–59. doi:10.1111/j.1365-2958.2006.05399.x. PMID 17076668.


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