ZFPM1

ZFPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XU7
Identifiers
Aliases	ZFPM1, FOG, FOG1, ZC2HC11A, ZNF408, ZNF89A, zinc finger protein, FOG family member 1
External IDs	MGI: 1095400 HomoloGene: 7606 GeneCards: ZFPM1
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription factor binding • transcription factor binding • metal ion binding • RNA polymerase II activating transcription factor binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • nucleic acid binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • cytoplasm • transcription factor complex • transcriptional repressor complex • nucleoplasm • nucleus Biological process • megakaryocyte development • megakaryocyte differentiation • negative regulation of mast cell differentiation • negative regulation of interleukin-4 biosynthetic process • negative regulation of fat cell differentiation • regulation of transcription, DNA-templated • homeostasis of number of cells • transcriptional activation by promoter-enhancer looping • positive regulation of interferon-gamma biosynthetic process • ventricular septum morphogenesis • outflow tract morphogenesis • platelet formation • blood coagulation • cardiac muscle tissue morphogenesis • negative regulation of transcription from RNA polymerase II promoter • negative regulation of protein binding • transcription, DNA-templated • regulation of chemokine production • atrial septum morphogenesis • heart development • atrioventricular valve morphogenesis • granulocyte differentiation • embryonic hemopoiesis • regulation of definitive erythrocyte differentiation • T-helper cell lineage commitment • primitive erythrocyte differentiation • mitral valve formation • tricuspid valve formation • definitive erythrocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • erythrocyte differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	161882	22761
Ensembl	ENSG00000179588	ENSMUSG00000049577
UniProt	Q8IX07	O35615
RefSeq (mRNA)	NM_153813	NM_009569
RefSeq (protein)	NP_722520.2	NP_033595.1
Location (UCSC)	Chr 16: 88.45 – 88.54 Mb	Chr 8: 122.28 – 122.34 Mb
PubMed search	[1]	[2]
Wikidata

Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG1) is a protein that in humans is encoded by the ZFPM1 gene.^[3] It is a cofactor of the GATA1 transcription factor.

References

Further reading

PDB gallery
1srk: Solution structure of the third zinc finger domain of FOG-1