VectorBase

VectorBase^[1]^[2] is one of the five Bioinformatics Resource Centers (BRC) funded by the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. VectorBase is focused on invertebrate vectors of human pathogens working with the sequencing centers and the research community to curate vector genomes (mainly genome annotation).

Genomes covered in the VectorBase database

Genome browser
Community annotation system
Microarray and gene expression repository
Controlled vocabularies for anatomy,^[5] insecticide resistance and vector-borne diseases (malaria and dengue fever)
BLAST searches for all covered genomes

↑ Lawson, D; Arensburger, P; Atkinson, P; Besansky, NJ; Bruggner, RV; Butler, R; Campbell, KS; Christophides, GK; et al. (2007). "VectorBase: a home for invertebrate vectors of human pathogens". Nucleic Acids Research. 35 (Database issue): D503–5. doi:10.1093/nar/gkl960. PMC 1751530. PMID 17145709.
↑ Lawson, D; Arensburger, P; Atkinson, P; Besansky, NJ; Bruggner, RV; Butler, R; Campbell, KS; Christophides, GK; et al. (2009). "VectorBase: a data resource for invertebrate vector genomics". Nucleic Acids Research. 37 (Database issue): D583–7. doi:10.1093/nar/gkn857. PMC 2686483. PMID 19028744.
↑ Nene, V; Wortman, JR; Lawson, D; Haas, B; Kodira, C; Tu, ZJ; Loftus, B; Xi, Z; et al. (2007). "Genome sequence of Aedes aegypti, a major arbovirus vector". Science. 316 (5832): 1718–23. Bibcode:2007Sci...316.1718N. doi:10.1126/science.1138878. PMC 2868357. PMID 17510324.
↑ Holt, RA; Subramanian, GM; Halpern, A; Sutton, GG; Charlab, R; Nusskern, DR; Wincker, P; Clark, AG; et al. (2002). "The genome sequence of the malaria mosquito Anopheles gambiae". Science. 298 (5591): 129–49. Bibcode:2002Sci...298..129H. doi:10.1126/science.1076181. PMID 12364791.
↑ Topalis, P; Tzavlaki, C; Vestaki, K; Dialynas, E; Sonenshine, DE; Butler, R; Bruggner, RV; Stinson, EO; et al. (2008). "Anatomical ontologies of mosquitoes and ticks, and their web browsers in VectorBase". Insect molecular biology. 17 (1): 87–9. doi:10.1111/j.1365-2583.2008.00781.x. PMID 18237287.

vectorbase.org
Bioinformatics Resource Centers The NIAID page describing the goals and activities of the BRCs
Pathogen Portal Hub site for the five BRCs; provides summary information

Bioinformatics

Databases	Sequence databases: GenBank, European Nucleotide Archive and DNA Data Bank of Japan Secondary databases: UniProt, database of protein sequences grouping together Swiss-Prot, TrEMBL and Protein Information Resource Other databases: Protein Data Bank, Ensembl and InterPro Specialised genomic databases: BOLD, Saccharomyces Genome Database, FlyBase, VectorBase, WormBase, PHI-base, Arabidopsis Information Resource and Zebrafish Information Network

Software	BLAST Bowtie Clustal HMMER MUSCLE SAMtools TopHat

Other	Server: ExPASy Ontology: Gene Ontology

Institutions	European Bioinformatics Institute US National Center for Biotechnology Information Swiss Institute of Bioinformatics Japanese Institute of Genetics Broad Institute Wellcome Trust Sanger Institute

Meetings	Intelligent Systems for Molecular Biology (ISMB) Research in Computational Molecular Biology (RECOMB) European Conference on Computational Biology (ECCB) Pacific Symposium on Biocomputing (PSB) ISCB Africa ASBCB Conference on Bioinformatics Basel Computational Biology Conference‎ ([BC²])

Computational biology List of biological databases Sequencing Sequence database Sequence alignment Molecular phylogenetics

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