U-50488
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| Identifiers | |
|---|---|
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| CAS Number |
67198-13-4  |
| PubChem (CID) | 3036289 |
| IUPHAR/BPS | 1652 |
| ChEBI |
CHEBI:73358  |
| ChEMBL |
CHEMBL441765 |
| Chemical and physical data | |
| Formula | C19H26Cl2N2O |
| Molar mass | 369.329 g/mol |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.[1] It has analgesic, diuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5]
See also
References
- ↑ Von Voigtlander, PF; Lewis, RA (1982). "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in neuro-psychopharmacology & biological psychiatry. 6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9. PMID 6298890.
- ↑ Kamei, J (1996). "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary pharmacology. 9 (5–6): 349–56. doi:10.1006/pulp.1996.0046. PMID 9232674.
- ↑ Hiramatsu, M; Kameyama, T (1998). "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and findings in experimental and clinical pharmacology. 20 (7): 595–9. doi:10.1358/mf.1998.20.7.485724. PMID 9819804.
- ↑ Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 52: 167–95. PMID 10396128.
- ↑ Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor. Part II: 1991-1998". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 53: 1–51. PMID 10616295.
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