Cherones began working in educational television while a student at the University of Alabama and later produced and directed programs for WQED in Pittsburgh. His first work after moving to Hollywood in 1975 was as a production manager for General Hospital.
Cherones began as a television director on My Sister Sam in the 1980s. In the 1990s, he became noted for directing and producing Seinfeld (81 episodes) and NewsRadio (56 episodes). His work on Seinfeld won him high praise as well as an Emmy, a DGA Award and a Golden Globe Award. In 2003, he was inducted into the Alabama Stage and Screen Hall of Fame. He was also inducted into the University of Alabama College of Communication and Information Sciences Hall of Fame in 2001.
For several years in the early 2000s, Cherones taught a film production course at the University of Alabama, where he had earned a Master's degree in 1976.
- "Four Distinguished Communication Leaders to be Inducted into C&IS Hall of Fame at UA". The University of Alabama. October 1, 2001. Retrieved May 13, 2016.
- "The Alabama Stage and Screen Hall of Fame". Theatretusc.com. Retrieved 2014-07-20.
- "Port Hole Publications". Port Hole Publications. Retrieved 2014-07-20.
- "HOME". The Hardly Boys. Retrieved 2014-07-20.
- Tom Cherones at the Internet Movie Database
- Tom Cherones interview video at the Archive of American Television