Tenascin X

TNXB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
Aliases TNXB, EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS, tenascin XB
External IDs MGI: 1932137 HomoloGene: 49589 GeneCards: TNXB
Genetically Related Diseases
age related macular degeneration, systemic lupus erythematosus, human immunodeficiency virus infectious disease[1]
Orthologs
Species Human Mouse
Entrez

7148

81877

Ensembl

n/a

ENSMUSG00000033327

UniProt

P22105

n/a

RefSeq (mRNA)

NM_032470
NM_019105

NM_031176

RefSeq (protein)

NP_061978.6
NP_115859.2

n/a

Location (UCSC) Chr 6: 32.04 – 32.12 Mb Chr 17: 34.67 – 34.72 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

A member of the tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB gene.[4]

Gene

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.[5]

Function

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing.[5]

Clinical significance

Deficiency causes one of the types of Ehlers-Danlos syndrome where collagen density is reduced and elastic fibers are fragmentated.[6]

References

  1. "Diseases that are genetically associated with TNXB view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
  5. 1 2 "Entrez Gene: tenascin XB".
  6. Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and tissue research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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